Irf family
WebThe interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. … WebIRFs primarily regulate type I IFNs in the host after pathogen invasion and are considered the crucial mediators of an antiviral response. Following a viral infection, pathogens are …
Irf family
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WebMar 21, 2024 · Also known as IIAE7 Summary This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a … WebThe interferon (IFN) regulatory factor (IRF) family of transcription factors plays a pivotal role in the development of immune cells and induction of cytokines that are important in immune and inflammatory responses ( 1, 2 ). The mammalian IRF …
WebAug 6, 2024 · IRFs are primarily related to the innate response of the immune system that is dependent on PRRs, including Toll-Like Receptor (TLR)s. IRFs comprise a family of nine homologous proteins (IRF1–9), which contain a conserved DNA binding domain and IRF association domain.
WebJan 18, 2024 · IRF family members can both homo- or hetero-dimerise forming either transcriptionally active or repressive complexes . Protein interactions within the IAD and … WebNov 30, 2012 · IRF family members possess an amino N-terminal DNA-binding domain (DBD) that is characterized by a series of five relatively well conserved tryptophan-rich repeats. All IRF family members, except for IRF1 and …
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